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British researchers examined a dozen clinical trials comparing topical NSAIDS with placebo or oral NSAIDS. According to the evidence, topical NSAIDS were more effective than placebo in relieving pain for the first two weeks of treatment, after which time they became virtually ineffective. Moreover, topical NSAIDS were less effective than oral NSAIDS during the first week of treatment and caused additional side-effects, including rash and itching; however, other studies have shown that oral anti-inflammatory drugs can have adverse side-effects when used over long periods of time, including upset stomach and ulcer. 
