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Clinical Nutrition
By G. Douglas Anderson, DC, DACBSP, CCN
Phytochemical Review
I remember in my first nutrition class, as a fourth-term student,
the teacher told us if people ate right, our country's health costs
would be radically reduced. There would be less cancer, less heart
disease, less diabetes, and less arthritis.
One of the other concepts emphasized in my nutrition classes in
chiropractic school was that there are many things beneficial to
humans in whole foods that we haven't discovered yet. The current
research on phytochemicals is proving this statement accurate. I
think all DCs should take pride in the fact that many who came
before us emphasized the importance of a healthy diet while our
allopathic friends under-emphasized or ignored the importance of
the link between good fuel and good health. Although I have and do
advocate vitamin and mineral supplementation, vitamins and minerals
are no substitute for the proper diet.
Phytochemicals are definitely the new hot topic in nutritional
research. I predict they will continue to make headlines the rest
of this decade and into the 21st century. Research on these plant
chemicals is so rapid that by the time you read this article, we
will probably have discovered more new compounds and have a better
understanding of the phytochemicals we have already isolated.
Initial research on many phytochemicals concerns the their
anticarcinogenic properties. When scientists reviewed the
literature about diet and cancer, they consistently found that
people who consumed high amounts of fruits and vegetables seemed to
have lower risk for various types of cancer, depending on the
fruits and vegetables they consumed. This trend was particularly
powerful when contrasted to vitamin studies which have had both
positive and negative outcomes in reducing the risk of cancer.
Researchers began to difficult task of isolating chemicals in
plants and realized there are hundreds, perhaps thousands of
bioactive compounds in whole foods. In the years to come, it will
1e fascinating to see new substances identified and how they
function alone, cooked, uncooked, and in combination with other
chemicals.
Many of the chemicals I will list for you today have only recently
been isolated and studied. The top chemical on the list, allyl
sulfides, which come from garlic and onions, have been extensively
studied for many years. The effects of this family of
phytochemicals should serve as a clue that as studies on other
phytochemicals continue, their functions and effects will be
expanded from what we currently understand. Finally, this list is
not all-encompassing, but it is designed to give you a ball park
idea of some of the chemicals that are now receiving attention and
that you will undoubtedly be reading about this year.
allyl sulfides garlic and onions antibacterial, antifungal,
antiseptic, antithrombotic,
anti-inflammatory, anti-
carcinogenic
alpha carotene carrots and pumpkins antioxidant with powerful
anticarcinogenic properties
betacrypto- oranges, tangerines carotenoid with antioxidant
xanthin papaya properties
brassinin cabbage antioxidant properties
which in animal studies
reduce tumors in the
breasts and skin
caffeic acid apples free radical scavenger
capsaicin peppers antioxidant especially good
at protecting DNA
chlorogenic acid tomatoes, bell blocks nitrosamine
peppers, pineapple, formation (nitrosamine is
strawberries a powerful carcinogen)
ellagic acid grapes, strawberries, antioxidant adept at
raspberries protecting DNA
dithiolthiones broccoli antioxidant which
specifically stimulates
enzymes in the glutathione
family (which are powerful
free radical scavengers)
epigallo- green tea This phytochemical in the
catechin polyphenol family
gallate gallate has been one
of the best
anticarcinogenic compounds
ever tested in animals,
inhibiting not only many
kinds of tumors but also
tumors in many different
stages (many natural compounds
can only fight metastatic
disease in the early stages).
genistein soybeans inhibits angiogenesis
indoles cruciferous vegetables stimulates the breakdown of
estrogen to estriol; other
estrogen breakdown
products, estradiol and
estrone, have been shown to
be both mutagenic and
carcinogen
isoflavones beans inhibits estrogen
metabolized from
penetrating cell membranes
in breast and ovarian
tissue; thus, it may
decrease the risk or
incidence of cancer in
these tissues
limonene citrus fruit antioxidant
lutein spinach, romaine carotenoids with anti
lettuce, red peppers, oxidant properties that
collard greens, Swiss have been shown to reduce
chard, mustard greens, the incidence of cataracts
okra
lycopene watermelon, guava, carotenoid and an
pink grapefruit, antioxidant which, in at least
tomatoes one study, was found to be
twice as powerful as beta
carotene, and has been
shown to be especially
beneficial in cancers of
the digestive tract.
Interestingly, this
chemical is quite stable
and is much higher in
canned tomato juices,
pastes, and sauces than in
raw tomatoes.
oltipraz cabbage and other antioxidant which
cruciferous vegetables stimulates glutathione
production
p-coumaric acid tomatoes, bell blocks nitrosamine
peppers, pineapple, formation
strawberries
phenethyl cruciferous vegetables antioxidant especially
isothiocyanates good at protecting DNA;
reduces estrogen to the
nontoxic metabolite
estradiol
phytosterols beans May inhibit some types of
colon cancer by a mechanism
that is not yet fully
understood.
sulforaphane broccoli, brussels antioxidant which in animal
sprouts, cauliflower, studies has been very
kale powerful at reducing breast
cancer in animals
zeaxanthin spinach, romaine Carotenoids with
lettuce, red peppers, antioxidant properties that
collard greens, Swiss have been shown to reduce
chard, mustard greens, the incidence of cataracts.
okra
Chlorophyll, which is found in all green vegetables, is turning out
to also have anticarcinogenic properties. Finally, all fruits and
vegetables also contain members of the flavonoid family, which is a
large family of compounds that have been shown to have
anti-inflammatory, immune-stimulating, and antioxidant properties.
There are hundreds, possibly thousands, of flavonoids just waiting
to be discovered.
In the coming years we will see many phytochemicals in tablet and
capsule form, as more are isolated and understood. There is no
doubt that as phytochemicals are put into tablet and capsule form
there will be uses and benefits for them. There is also no doubt
that the best source of these powerful nutrients is whole foods. I
hope marketers don't take the angle that cheeseburgers, fries, and
shakes are okay as long as you take a handful of their "phytotabs."
G. Douglas Andersen, DC, DACBSP, CCN
Brea, California
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